Some of the main invasive alien plants in the Garden Route include the following:
- Acacia mearnsii (Black wattle)
- Ricinus communist (Castor oil plant)
- Solanum mauritianum (Bugweed)
- Acacia melanoxylon (Blackwood)
- Acacia Saligna (Port Jackson)
- Acacia cyclops (Rooikrans)
- Cortaderia selloana (Pampas grass)
- Lantana camara (Lantana)
- Pinus pinaster (Cluster pine)
- Rubus cuneifolius (American bramble)
- Eucalyptus spp (Gum)
- Pinus radiata (Radiata pine)
- Salix babylonica (Weeping willow)
- Acacia melanoxylon (Blackwood)
- Paraserianthes lophantha (Stink bean)
- Arundo donax (Giant reed)
- Anredera cordifolia (Madeira Vine)
- Casuarina cunninghamiana (Casuarinaceae) (Beefwood)
- Sesbania punicea (Red sesbania)
- Hakea sericea (Hakea / Silky Hakea)
- Acacia longifolia (Long leave wattle)
- Eucalyptus ficifolia (Flowering Gum)
- Agave sisalana (Sisal)
- Leptospermum laevigatum (Australian Myrtle/Coast tea tree)